Small sample properties of rare variant analysis methods

Small sample properties of rare variant analysis methods

We are now well into the sequencing era of genetic analysis, and methods to investigate rare variants associated with disease remain in high demand. Currently, the more common rare variant analysis methods are burden tests and variance component tests. This report introduces a burden test known as the modified replication based sum statistic and evaluates its performance, and the performance of...

Small Variant Assembler Methods

Rare variant association analysis methods for complex traits.

There has been increasing interest in rare variants and their association with disease, and several rare variant-disease associations have already been detected. The usual association tests for common variants are underpowered for detecting variants of lower frequency, so alternative approaches are required. In addition to reviewing the association analysis methods for rare variants, we discuss...

The Bootstrap Small Sample Properties

This report reviews several bootstrap methods with special emphasis on small sample properties. Only those bootstrap methods are covered which promise wide applicability. The small sample properties can be investigated analytically only in parametric bootstrap applications. Thus there is a strong emphasis on the latter although the bootstrap methods can be applied nonparametrically as well. The...

Rare Variant of Lycanthropy and Ecstasy

Abstract Background: Lycanthropy is an unusual belief or delusion in which the patient thinks that he/she has been transformed into an animal. In rare cases, the patient believes that another person has been transformed into an animal. Case Report: We report a patient with an uncommon variant of lycanthropy is introduced. The symptoms appeared after consumption of ecstasy. This show...